Take out some of each and pattern it,see what works best in your gun. I killed a boar that dressed at over 350 pounds with a face hit from 2 3/4 #1's. Ive used everything from 000 to #4 buck all will kill at shotgun ranges.If your gun patterns both equally then stick with the bigger shot that will retain more enegry,penetrate deeper. I have a 1300 winnie pump that will put a pattern of #4 buck in about 18" at 35 yards,that will shred the heart lung area on a deer.with 00 in the same gun ,choke,at that range you get aproximatly 3 out of 9 pellets in.Hammer Man