I've shot a half-dozen Mulies (go to Wyoming or Colorado once every 4 or 5 years), and they don't taste much different than a whitetail - the meat may be a little drier and stringier would be the only difference I noticed - and that was very slight.
Like any game meat, there is good mule deer and bad mule deer venison. The last two mulies I shot were delicious. Even my very picky 14 year old daughter liked them and is happy when we have mulie for dinner.
Depends what they have been eating, and if they are properly cared for after being shot.
I think also that venison is an acquired taste for some people. There are folks that just don't like it, even when it's the good version.
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