For sure! Here's a group I shot the other night with my 45cal 10MLII. Not a great group ~2.1" CTC, but wind was swirling around at about 15MPH. I'm shooting a pretty standard load at around 2650-2700FPS with a 200gr bullet. As you can see, I'm a touch low at 140. I shot a couple of shots at 56 yards the other day and was a 1/2" low. It's very flat shooting.jcchartboy said:A modern muzzleloader, and specific a modern smokelss muzzlleloader, absolutely will however. (As is evidenced by there ever increasing popularity for whitetail hunting).