If you find the right load, a cylinder bore bore can deliver decent accuracy with slugs if you have good sights.
Each gun will have different preferences, requiring you to try several brands and types. In general stay away from slug loads designed for rifled barrels.
I have had excellent success with 12 ga. Fiocchi Exacta Aero Slugs (7/8 oz) in an M500 with 18.5" cylinder barrel. From the bench three shot groups at 50 yards were <3", and at 100 yards ~ 6" - both when the wind wasn't blowing. This gun does have peep sights, and special targets were used to help with aiming consistency.
Brenneke slugs also grouped pretty well for me, and Remington Buckhammers did respectably, but neither were as good as the Fiocchi's. All other brands did poorly for me, but may work great in another gun.